Publications by authors named "C R Ono"
Introduction: The SARS-CoV-2 pandemic has had a widespread and severe impact on society, yet there have also been instances of remarkable recovery, even in critically ill patients.
Materials And Methods: In this study, we used single-cell RNA sequencing to analyze the immune responses in recovered and deceased COVID-19 patients during moderate and critical stages.
Results: Expanded T cell receptor (TCR) clones were predominantly SARS-CoV-2-specific, but represented only a small fraction of the total repertoire in all patients.
Article Synopsis
- The study aimed to explore how physical and chemical digestion factors correlate with nutrition markers like serum albumin, prealbumin, and vitamin B levels in 92 participants at Fujita Health University.
- Key findings showed that while physical digestion measures (like chewing and swallowing ability) did not significantly impact serum nutrition markers, there was a notable link between oral antacid use and decreased prealbumin levels.
- The study concluded that using oral antacids might lower serum prealbumin, suggesting an effect on protein synthesis in the body.
Whereas severe COVID-19 is often associated with elevated autoantibody titers, the underlying mechanism behind their generation has remained unclear. Here we report clonal composition and diversity of autoantibodies in humoral response to SARS-CoV-2. Immunoglobulin repertoire analysis and characterization of plasmablast-derived monoclonal antibodies uncovered clonal expansion of plasmablasts producing cardiolipin (CL)-reactive autoantibodies.
View Article and Find Full Text PDFIdentification of risk loci for postpartum depression in a genome-wide association study.
Psychiatry Clin Neurosci
November 2024
Aim: Genome-wide association studies (GWAS) of postpartum depression (PPD) based on accumulated cohorts with multiple ethnic backgrounds have failed to identify significantly associated loci. Herein, we conducted a GWAS of Japanese perinatal women along with detailed confounding information to uncover PPD-associated loci.
Methods: The first and second cohorts (n = 9260 and n = 8582 perinatal women enrolled in the Tohoku Medical Megabank Project) and the third cohort (n = 997), recruited at Nagoya University, underwent genotyping.