Characterization of sulfur mustard vapor-induced cutaneous lesions on haired guinea pigs.

Background/aims: Sulfur mustard (2,2'-dichlorodiethyl sulfide, HD) is a potent vesicating (blistering) agent. In this report, we describe the time-course and the dose-dependent response following cutaneous exposure to sulfur mustard (HD) in the haired guinea pig model. The purpose of this study was to evaluate the usefulness of the haired guinea pig as a vesicant research model.