Publications by authors named "C R Mains"
Article Synopsis
- SARS-CoV-2 causes a range of COVID-19 disease severities, influenced by immune responses that are affected by variants like Omicron.
- * The protein C1 esterase inhibitor (C1-INH), which regulates the immune system, is found at higher levels in severe COVID-19 cases and may paradoxically worsen the disease.
- * This review discusses C1-INH’s role in immune response and explores current clinical trials testing exogenous C1-INH treatment for COVID-19.
Article Synopsis
- Whole blood (WB) resuscitation in pediatric trauma patients shows potential safety and mortality benefits compared to traditional blood component therapy (BCT).
- A study analyzed 90 pediatric trauma patients from ten level-I trauma centers, comparing those who received WB versus those who received BCT during resuscitation.
- Results indicated no significant differences in mortality or complications between the two groups, suggesting that using WB is a safe option for critically injured pediatric patients.
Objective: Early identification of the subset of trauma patients with acute hemorrhage who require resuscitation via massive transfusion protocol (MTP) initiation is vital because such identification can ensure the availability of resuscitation products immediately upon hospital arrival and result in improved clinical outcomes, including reduced mortality. However, there are currently few studies on the predictors of MTP in the unique setting of flight transport.
Methods: This was a retrospective study of adult trauma patients transported from the scene via flight to 6 trauma centers between March 1, 2019, and January 21, 2021.