Publications by authors named "C R Kothari"
Next-generation cancer nanotherapeutics: Pluronic F127 based mixed micelles for enhanced drug delivery.
Naunyn Schmiedebergs Arch Pharmacol
November 2024
Cancer, projected to become the second leading cause of mortality globally, underscores the critical need for precise drug delivery systems. Nanotechnology, particularly micelles, has emerged as a promising avenue. These nano-sized colloidal dispersions (< 100 nm) utilize amphiphilic molecules featuring a hydrophilic tail and hydrophobic core, facilitating efficient drug encapsulation and delivery.
View Article and Find Full Text PDFIntroduction: In the United States, maternal mortality is high and patterned by race and socioeconomic status (SES). Patient-provider relationships and societal discrimination have been separately associated with poor maternal outcomes, but it is not clear how such mechanisms may be interrelated. Thus, the present study investigates how societal experiences of discrimination are associated with and manifest in patient-provider relationship quality among perinatal women.
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- Phelan-McDermid syndrome (PMS) is a rare neurodevelopmental disorder linked to deletions of the 22q13 region, particularly affecting the SHANK3 gene, leading to various developmental challenges like intellectual disabilities and autism.
- Researchers conducted a study using the PMS International Registry to analyze clinical and genetic data from 401 individuals to understand how the size of deletions affects their clinical features.
- Findings revealed that larger deletions were associated with more severe developmental delays and physical issues, while individuals with smaller deletions or specific SHANK3 variants tended to show better self-help and verbal skills along with various psychiatric diagnoses.
Background: Hematoxylin & Eosin (H & E) stains have been conventionally used to establish the status of safe margins following resection of primary Oral Squamous Cell Carcinoma. Due to non-specificity of this stain, there is a possibility of false negative results. In this study, we have assessed the role of Immunohistochemistry (IHC) in establishing the status of safe margins.
View Article and Find Full Text PDFHome visiting programs have been found to improve parenting practices and to reduce negative child outcomes. The 2019 coronavirus disease (COVID-19) resulted in an abrupt transition to telehealth services for many home visiting services. Limited research has examined the impacts of delivering home visiting services via telehealth, and the effects of this abrupt transition during COVID-19 is understudied as well.
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