Fuller Albright and our current understanding of calcium and phosphorus regulation and primary hyperparathyroidism.

The major contributions of Fuller Albright to our understanding of calcium and phosphorus regulation and primary hyperparathyroidism are highlighted. Albright was the first investigator to initiate a systematic study of mineral metabolism. With resources limited to the measurement of serum calcium and phosphorus and the infusion of parathyroid extract, Albright used balance studies to establish a framework for our understanding of calcium and phosphorus regulation and primary hyperparathyroidism.

The journey from vitamin D-resistant rickets to the regulation of renal phosphate transport.

In 1937, Fuller Albright first described two rare genetic disorders: Vitamin D resistant rickets and polyostotic fibrous dysplasia, now respectively known as X-linked hypophosphatemic rickets (XLH) and the McCune-Albright syndrome. Albright carefully characterized and meticulously analyzed one patient, W.M.

Now and then, the history of parenteral fluid administration.

The use of blood and intravenous fluid therapy is now considered routine therapy. The level of sophistication that we now perceive as standard has resulted from centuries of legends, religious beliefs, pseudo-science, non-scientific supposition, experimentation and error. The purpose of this article is to review the evolution of parenteral fluid and transfusion therapy through history.