Publications by authors named "C R Kahlert"
Background And Aims: Dried blood spots (DBS) have been proposed as a cost-effective surveillance method for population-wide screening of SARS-CoV-2 immunity but sensitivity of DBS based on self-collected DBS samples is unknown. To evaluate the success of vaccination strategies, it is necessary to differentiate vaccination from natural infection. Therefore, a test for antibodies against the viral nucleocapsid protein (anti-N) is desirable.
View Article and Find Full Text PDFUrease-producing bacteria are highly relevant in medicine due to their role in various pathogenic processes and their impact on human health, causing serious medical conditions such as peptic ulcer disease, gastric cancer, and respiratory and urinary tract infections. In this work, we designed fluorescent polymeric particles (PNP_FITC) to enable the detection of urease-producing bacteria by targeting the enzymatic activity of urease. In particular, the PNP_FITC matrix is degraded by urease, leading to a measurable increase in the intensity of the fluorescent signal.
View Article and Find Full Text PDFBackground: Artificial intelligence (AI) offers potential support in patient-clinician interactions, but its impact on such communication remains unexplored.
Methods: In this study, ChatGPT was compared with two pancreatic surgeons in responding to ten pancreatic cancer surgery-related questions, co-designed with the Patient Advisory Board of the Surgical Society's Study Center. A blind evaluation of these responses, considering content congruency and clarity for non-specialists, was conducted by patients and surgeons.
Article Synopsis
- Cachexia, a condition linked to cancer and associated with a poor prognosis, accounts for about 20% of cancer-related deaths, yet the connection between Fusobacterium nucleatum (Fn) and cachexia in colorectal cancer (CRC) remains unclear.
- In a study involving 87 CRC patients, researchers found that high levels of Fn in pre-surgical stool samples significantly increased the risk of developing cachexia six months after surgery.
- These results are the first to connect Fn abundance with cachexia in CRC, highlighting potential biological mechanisms and treatment avenues; however, the study's small sample size calls for more research to confirm these findings.
Purpose: As healthcare workers (HCW) have been disproportionally affected by COVID-19, its post-acute sequelae (PASC) in HCW can impact healthcare systems. We assessed the burden and course of PASC in HCW over a 30-month period.
Methods: In a prospective multicentre HCW cohort in Switzerland, PASC surveys were conducted in 03/2021, 09/2021, 06/2022, 04/2023, and 10/2023.