Publications by authors named "C R Hutchinson"
Purpose: This study sought to identify barriers and facilitators to the employment of people with disabilities in small-to-medium-sized enterprises (SMEs) in hospitality.
Methods: Semi-structured interviews were conducted with hospitality employers ( = 35). Purposive sampling was used to recruit employers with varied experiences of employing people with disability.
Purpose: Older people (aged ≥ 65 years) are significant users of health and social care systems. However, many outcome measures for quality assessment and economic evaluation lack content validation for this population. Cognitive interviews are a key approach for generating content validity evidence.
View Article and Find Full Text PDFArticle Synopsis
- Over the past century, improvements in structural metals have led to complex chemical compositions that raise costs and recycling challenges.
- Metal 3D-printing presents a way to simplify alloy compositions, making it possible to use plain carbon steels while achieving high performance comparable to ultra-high strength alloys like Maraging steels.
- Through precise control of 3D-printing parameters, the ability to tailor microstructures and properties offers a scalable solution to reduce alloy complexity while maintaining strong mechanical performance.
Molecularly imprinted polymers (MIPs) are a class of synthetic recognition materials that offer a cost-effective and robust alternative to antibodies. While MIPs have found predominant use in biosensing and diagnostic applications, their potential for alternative uses, such as enzyme inhibition, remains unexplored. In this work, we synthesized a range of acrylamide-based hydrogel MIP microparticles (35 μm) specific for the recognition of α-amylase.
View Article and Find Full Text PDFIntraduodenal fecal microbiota transplantation ameliorates gut atrophy and cholestasis in a novel parenteral nutrition piglet model.
Am J Physiol Gastrointest Liver Physiol
November 2024
Article Synopsis
- Total parenteral nutrition (TPN) is a lifesaving IV feeding method but can cause serious side effects like gut microbial changes and liver injury.
- A study involving 31 piglets tested the effects of transferring fecal microbiota from healthy pigs to those on TPN, with various groups including a control, TPN alone, TPN with antibiotics, and TPN with fecal transplant.
- The results showed that fecal microbiota transplant (FMT) helped prevent gut atrophy, liver injury, and harmful microbial changes seen in TPN, suggesting that gut microbes could be critical for developing new treatments.