Publications by authors named "C R Hay"
Signal transduction downstream of activating stimuli controls CD8+ T cell biology, however these external inputs can become uncoupled from transcriptional regulation in Primary Immune Regulatory Disorders (PIRDs). Gain-of-function (GOF) variants in STAT3 amplify cytokine signaling and cause a severe PIRD characterized by early onset autoimmunity, lymphoproliferation, recurrent infections, and immune dysregulation. In both primary human and mouse models of STAT3 GOF, CD8+ T cells have been implicated as pathogenic drivers of autoimmunity.
View Article and Find Full Text PDFObjectives: The 24-month, prospective, non-interventional, European multicenter A-SURE study evaluated the real-world effectiveness of prophylaxis using an extended half-life recombinant factor VIII (FVIII) Fc fusion protein, efmoroctocog alfa (hereinafter rFVIIIFc), compared with prophylaxis using standard half-life (SHL) FVIII products in patients with hemophilia A.
Methods: Primary endpoints were annualized bleeding rate (ABR), annualized injection frequency, and annualized factor consumption. A comparative study design unique for an observational hemophilia study was implemented to reduce potential confounding in effectiveness estimates, wherein each patient prescribed rFVIIIFc was matched with one receiving SHL FVIII.
Article Synopsis
- Lipid vesicles, which can encapsulate biological and non-biological materials, show promise for drug delivery (under 100 nm) and model membranes for biophysics studies (over 1 μm), pushing advancements in various fields like nanomedicine and synthetic biology.
- There's a growing need for cutting-edge technologies, especially microfluidic methods, which offer better size control, higher production rates, and customizable properties compared to traditional techniques.
- The review covers recent developments in microfluidic lipid vesicle generation, discussing different technologies, their pros and cons, and the future potential for creating new therapeutic applications and bio-inspired devices.
Swearing, or the use of taboo language, has been repeatedly shown to induce hypoalgesia. While reliable hypoalgesic effects have been observed across studies, the mechanisms by which swearing influences pain and the optimal dosage of swearing remain poorly understood. Plausible mechanistic rationale for swearing's impact on pain include sympathetic response, emotion, humor, distraction, aggression, state disinhibition, psychological flow, risky behavior, and self-confidence.
View Article and Find Full Text PDFArticle Synopsis
- * A study involving 88 critically ill pediatric patients identified three immune subphenotypes linked to clinical outcomes, indicating meaningful differences in immune dysregulation between patients with and without sepsis.
- * The research highlighted the role of STAT3 hyperactivation in lymphocytes, particularly in the sickest subgroup of patients, suggesting that targeting this dysregulated pathway could improve treatment for severe cases of multiple organ dysfunction syndrome (MODS).