Enhanced warming of European mountain permafrost in the early 21st century.

Mountain permafrost, constituting 30% of the global permafrost area, is sensitive to climate change and strongly impacts mountain ecosystems and communities. This study examines 21st century permafrost warming in European mountains using decadal ground temperature data from sixty-four boreholes in the Alps, Scandinavia, Iceland, Sierra Nevada and Svalbard. During 2013-2022, warming rates at 10 metres depth exceed 1 °C dec in cases, generally surpassing previous estimates because of accelerated warming and the use of a comprehensive data set.

Systematic literature review and meta-analysis on the prevalence of rotavirus genotypes in Europe and the Middle East in the post-licensure period.

Previous systematic literature reviews of rotavirus genotype circulation in Europe and the Middle East are limited because they do not include country-specific prevalence data. This study documents country-specific evidence on the prevalence of rotavirus genotypes in Europe and the Middle East to enable more precise epidemiological modeling and contribute to the evidence-base about circulating rotavirus genotypes in the post-vaccination era. This study systematically searched PubMed, Embase and Scopus for all empirical epidemiological studies that presented genotype-specific surveillance data for countries in Europe and the Middle East published between 2006 and 2021.

A flexible loop in the paxillin LIM3 domain mediates its direct binding to integrin β subunits.

Integrins are fundamental for cell adhesion and the formation of focal adhesions (FA). Accordingly, these receptors guide embryonic development, tissue maintenance, and haemostasis but are also involved in cancer invasion and metastasis. A detailed understanding of the molecular interactions that drive integrin activation, FA assembly, and downstream signalling cascades is critical.