Pollen-pistil interaction in Mauritia flexuosa: structural and cytological aspects provide insight into the reproductive success of a dioecious palm with supra-annual flowering in a semiarid environment.

The success of pollen-pistil interaction in Mauritia flexuosa (buriti), a palm adapted to the humid ecosystems, 'veredas', within the Cerrado, is influenced by intrinsic and environmental factors. Its supra-annual flowering, dioecy, and adverse climate conditions pose challenges for fertilization, therefore information on floral biology is essential. This study aimed to ascertain stigma receptivity, and elucidate structural, cytochemical, and ultrastructural aspects of the pollen-pistil relationship.

Feline Aural Inflammatory Polyps.

Feline aural inflammatory polyps originate from the tympanic bulla and less frequently from the auditory tube, representing the most common benign tumor of the feline ear. Clinical signs may be compatible with otitis externa, media, and/or interna with rare occurrences involving meningoencephalitis or abscessation of periauricular tissue. Traction and avulsion is an effective treatment procedure with a relatively low recurrence rate, especially when systemic glucocorticoids are given after polyp removal.

WT161, a selective HDAC6 inhibitor, decreases growth, enhances chemosensitivity, promotes apoptosis, and suppresses motility of melanoma cells.

Purpose: Histone deacetylase 6 (HDAC6) plays a critical role in tumorigenesis and tumor progression, contributing to proliferation, chemoresistance, and cell motility by regulating microtubule architecture. Despite its upregulation in melanoma tissues and cell lines, the specific biological roles of HDAC6 in melanoma are not well understood. This study aims to explore the functional effects and underlying mechanisms of WT161, a selective HDAC6 inhibitor, in melanoma cell lines.

Evaluation of a biomarker for amyotrophic lateral sclerosis derived from a hypomethylated DNA signature of human motor neurons.

Amyotrophic lateral sclerosis (ALS) lacks a specific biomarker, but is defined by relatively selective toxicity to motor neurons (MN). As others have highlighted, this offers an opportunity to develop a sensitive and specific biomarker based on detection of DNA released from dying MN within accessible biofluids. Here we have performed whole genome bisulfite sequencing (WGBS) of iPSC-derived MN from neurologically normal individuals.

EPIDEMIOLOGICAL PROFILE OF PATIENTS WITH ANKLE FRACTURE TREATED IN A TERTIARY LEVEL HOSPITAL.

Objective: To evaluate the epidemiological profile of patients diagnosed with ankle fracture admitted to a tertiary hospital.

Methods: Retrospective Cross-Sectional Observational Study.

Inclusion Criteria: Individuals aged ≥18 (eighteen) years, diagnosed with ankle fracture, who underwent surgical and/or conservative treatment at a tertiary hospital in the city of São Paulo.