Publications by authors named "C R Dass"
Article Synopsis
- Point of Care Ultrasound (POCUS) is used to assess pleural movement in patients with advanced emphysema, but its effectiveness in these patients is not well established.
- A study evaluated ultrasound findings in 48 COPD patients and found a significant number showed abnormal patterns, such as absent lung sliding or a barcode appearance.
- Results indicated there is limited correlation between ultrasound abnormalities and standard lung function measures, highlighting a need for cautious interpretation of POCUS in these cases.
Article Synopsis
- Chronic thromboembolic pulmonary hypertension (CTEPH) can occur when acute pulmonary embolism does not fully resolve, and the study investigates whether changes in CT Hounsfield Unit gradient (HU-Δ) can indicate low cardiac index (CI).
- A retrospective analysis of 237 CTEPH patients revealed that higher HU-Δ values between the main pulmonary artery (MPA) and both the left atrium (LA) and left ventricle (LV) were associated with low CI, showing distinct statistical differences.
- The study found that certain HU-Δ thresholds could effectively predict low CI, demonstrating high sensitivity and reproducibility, suggesting these measurements might be useful markers in clinical
Article Synopsis
- This review focuses on treatment options for oropharyngeal squamous cell carcinoma (OPSCC), highlighting its molecular mechanisms within head and neck cancers.
- Treatment approaches can either be radical (aimed at curing the disease) or palliative (focused on disease control and relieving symptoms).
- Key findings show that radiotherapy is the primary treatment choice for OPSCC in many countries, while surgical options are limited; molecular therapies are still mainly in preclinical stages, with several drugs currently undergoing clinical testing.
A novel organic-inorganic gliclazide-loaded composite bead was developed by an ionic gelation process using acidified CaCl, chitosan and tetraethylorthosilicate (TEOS) as a crosslinker. The beads were manufactured by crosslinking an inorganic silicone elastomer (-OH terminated polydimethylsiloxane, PDMS) with TEOS at different ratios before grafting onto an organic backbone (Na-alginate) using a 3 factorial experimental design. Gliclazide's encapsulation efficiency (EE%) and drug release over 8 h (% DR 8 h) were set as dependent responses for the optimisation of a pharmaceutical formula (herein referred to as 'G op') by response surface methodology.
View Article and Find Full Text PDFPigment epithelium-derived factor (PEDF), a serine protease inhibitor (Serpin) family member, shows promise in inhibiting tumour growth. In our study, we explored the effects of PEDF on the efficacy of the frontline chemotherapy agent doxorubicin (Dox) in BC cells. We found that Dox+PEDF treatment significantly reduced glucose uptake in MDA-MB-231 cells compared to the control ( = 0.
View Article and Find Full Text PDF