Publications by authors named "C R Carlin"
Article Synopsis
- SARS-CoV-2 is evolving, resulting in new variants like XEC, which has specific mutations (T22N and F59S) in the spike protein that affect how the virus interacts with neutralizing antibodies.
- The study analyzed immune responses from different vaccinated groups and found that XEC had significantly lower neutralization levels due to the F59S mutation, but removing certain glycosylation sites could restore these levels.
- The research highlights that mutations in the N-terminal domain of the spike protein play a crucial role in the virus's ability to evade the immune system and change its structural properties.
The prevalence of long-term conditions such as cardiovascular disease, chronic obstructive pulmonary disease (COPD), asthma, and diabetes mellitus is rising. These conditions are leading sources of premature mortality, hospital admission, and healthcare expenditure. Machine learning approaches to improve the management of these conditions have been widely explored, with data-driven insights demonstrating the potential to support earlier diagnosis, triage, and treatment selection.
View Article and Find Full Text PDFImportance: Medicare Advantage (MA) has grown significantly over the last decade; however, MA's performance for patients with serious conditions, such as cancer, remains unclear.
Objective: To compare resource use and care quality between MA and traditional Medicare (TM) beneficiaries undergoing cancer chemotherapy.
Design, Setting, And Participants: This cohort study used TM claims and MA encounter records from January 2015 to December 2019.
Article Synopsis
- In the summer of 2024, a global increase in COVID-19 cases was attributed to JN.1 subvariants of SARS-CoV-2, which have new mutations, particularly in the spike protein's N-terminal domain (NTD).
- The study found that several subvariants (LB.1, KP.2.3, KP.3, and KP.3.1.1) largely escape neutralizing antibodies from various vaccines and past infections due to a key deletion (DelS31) in the spike protein.
- The DelS31 mutation enhances the stability of the spike protein and introduces changes that help the virus avoid immune detection, suggesting a possible need to update COVID-19 vaccines to include antigens
Article Synopsis
- This study examines how subvariants of JN.1 (SLip, FLiRT, and KP.2) respond to neutralization by antibodies from vaccinated people and infected patients, discovering they show increased resistance compared to the original JN.1.
- The research finds that while hamster sera from XBB.1.5 vaccinations can strongly neutralize FLiRT and KP.2, SLip has reduced neutralization effectiveness. All subvariants demonstrate resistance to the antibody S309 and show decreased infectivity and other functionalities compared to JN.1.
- Key mutations in the spike protein of these subvariants are identified, affecting their interaction with antibodies and suggesting that new vaccines might need to