Publications by authors named "C R Barthelemy"
Background: Intravenous (IV) access is often required for the treatment of vaso-occlusive crises in patients with sickle cell disease, but can be particularly challenging due to recurrent venous damage. The AccuVein® device, uses near-infrared light technology to visualise veins for easier venepuncture.
Methods: A randomised, controlled trial of the efficacy of the AccuVeinAV400® device in the replacement of peripheral venous lines during a vaso-occlusive crisis was conducted at two centres in France.
Continuous compensation for cerebral dopamine deficiency represents an ideal treatment for Parkinson's disease. Dopamine does not cross the digestive and blood-brain barriers and is rapidly oxidized. The new concept is the intracerebroventricular administration of anaerobic dopamine (A-dopamine) using an abdominal pump connected to a subcutaneous catheter implanted in the third ventricle, near the striatum.
View Article and Find Full Text PDFArticle Synopsis
- The announcement of Parkinson's disease (PD) diagnosis often leads to negative emotions for patients, impacting their coping strategies and overall adjustment to the condition.
- A national French survey involving 397 recent PwPD, along with their caregivers and healthcare professionals, found that 60% of patients were not expecting their diagnosis and 82% experienced negative feelings, particularly influenced by male gender and older age.
- There is a significant need for improved communication and support during the diagnosis process, as many PwPD and caregivers felt they lacked sufficient information and expressed a desire for multidisciplinary follow-up.
Synapse and primary cilia dysfunctions in Autism Spectrum Disorders. Avenues to normalize these functions.
Rev Neurol (Paris)
December 2024
Aim: An update on the plasticity of the brain networks involved in autism (autism spectrum disorders [ASD]), and the increasing role of their synapses and primary non-motile cilia.
Methods: Data from PubMed and Google on this subject, published until February 2024, were analyzed.
Results: Structural and functional brain characteristics and genetic particularities involving synapses and cilia that modify neuronal circuits are observed in ASD, such as reduced pruning of dendrites, minicolumnar pathology, or persistence of connections usually doomed to disappear.
People with Parkinson's disease with motor fluctuations can be treated by continuous subcutaneous apomorphine infusion (CSAI) to reduce their symptoms. Nonetheless, factors are lacking to predict patients' quality-of-life amelioration after CSAI. This pilot study aimed to evaluate associations between personality dimensions and quality-of-life improvement after 6 months of CSAI.
View Article and Find Full Text PDF