Publications by authors named "C R Bangham"
Background: With US Centers for Disease Control and Prevention funding, from 2018 to 2022, 4 large healthcare systems (n = 53 health centers across 7 states) serving people of reproductive age trained staff and provided implementation support for alcohol screening and brief intervention (SBI). This cross-site evaluation explores each healthcare system's implementation approach to implement SBI, reduce excessive alcohol use, and prevent prenatal alcohol exposure (PAE) and fetal alcohol spectrum disorders.
Methods: The SBIRT (Screening, Brief Intervention, and Referral to Treatment) Program Matrix framed the multilevel strategies to implement alcohol SBI programs from 2018 to 2022.
Article Synopsis
- - A typical individual infected with HTLV-1 has over 10,000 different T cell clones, each containing a unique HTLV-1 provirus affecting host genome transcription and chromatin structure.
- - Researchers investigated whether the negative effects on host transcription and chromatin loops were due to the presence of the provirus or its activity by analyzing T cells based on proviral expression.
- - They discovered that while proviral transcription leads to abnormal transcription and splicing in adjacent genes, it actually suppresses the formation of abnormal chromatin loops, and reducing this transcription can restore normal chromatin interactions.
Human T cell leukemia virus type 1 (HTLV-1) is a retrovirus with preferential CD4+ T cell tropism that causes a range of conditions spanning from asymptomatic infection to adult T cell leukemia and HTLV-1-associated myelopathy (HAM), an inflammatory disease of the CNS. The mechanisms by which HTLV-1 induces HAM are poorly understood. By directly examining the ex vivo phenotype and function of T cells from asymptomatic carriers and patients with HAM, we show that patients with HAM have a higher frequency of CD4+CD8+ double-positive (DP) T cells, which are infected with HTLV-1 at higher rates than CD4+ T cells.
View Article and Find Full Text PDFBackground: There is growing demand for developmental and behavioral pediatric services including autism evaluation and care management. Clinician trainings have been found to result in an increase of knowledge and attitudes. This study utilizes Normalization Process theory (NPT) to evaluate a clinician training program and its effects on practice.
View Article and Find Full Text PDFThis study assessed relationship between adverse economic events (AEE) and hunger level (i.e., little to no, moderate, severe).
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