Advances in Research of Hydrogel Microneedle-Based Delivery Systems for Disease Treatment.

Microneedles (MNs), composed of multiple micron-scale needle-like structures attached to a base, offer a minimally invasive approach for transdermal drug delivery by penetrating the stratum corneum and delivering therapeutic agents directly to the epidermis or dermis. Hydrogel microneedles (HMNs) stand out among various MN types due to their excellent biocompatibility, high drug-loading capacity, and tunable drug-release properties. This review systematically examines the matrix materials and fabrication methods of HMN systems, highlighting advancements in natural and synthetic polymers, and explores their applications in treating conditions such as wound healing, hair loss, cardiovascular diseases, and cancer.

Novel Nuclease MbovP701 with a Yqaj Domain Is Interrelated with the Growth of .

() is characterized by a reduced genomic size and limited synthetic capacity, including the inability to synthesize nucleotides de novo, relies on nucleases for nutrient acquisition and survival. A number of nucleases have been implicated in pathogenicity, facilitating substrate degradation and contributing to DNA repair mechanisms that enhance bacterial persistence. The present study confirmed that the T5.

Bioremediation Potential of PM1 in Sodium Selenite-Contaminated Soil and Its Impact on Microbial Community Assembly.

Soil microbial communities are particularly sensitive to selenium contamination, which has seriously affected the stability of soil ecological environment and function. In this study, we applied high-throughput 16S rRNA gene sequencing to examine the effects of low and high doses of sodium selenite and the selenite-degrading bacterium, PM1, on soil bacterial community composition, diversity, and assembly processes under controlled laboratory conditions. Our results indicated that sodium selenite and strain PM1 were key predictors of bacterial community structure in selenium-contaminated soils.

Characterization of the Mitochondrial Genome of (Astacidea: Cambaridae) and Its Phylogenetic Implications.

Background: is an endangered freshwater crayfish in China, belonging to the genus Cambaroides, that can act as a complementary host for paragonimus. The objective of this study was to examine the complete mitochondrial genome characteristics and their evolutionary relationships within the Astacidea.

Methods: The analysis of gene rearrangements and evolutionary relationships was conducted through the sequencing of the mitochondrial genome of .

Genomic and Gut Microbiome Evaluations of Growth and Feed Efficiency Traits in Broilers.

In this study, we combined genomic and gut microbiome data to evaluate 13 economically important growth and feed efficiency traits in 407 Dahen broilers, including body weight (BW) at four, six, nine, and ten weeks of age (BW4, BW6, BW9, and BW10), as well as the average daily gain (ADG6, ADG9, and ADG10), feed conversion ratio (FCR6, FCR9, and FCR10), and residual feed intake (RFI6, RFI9, and RFI10) for the three growing ages. The highest ADG and lowest FCR were observed at nine and six weeks of age, respectively. We obtained 47,872 high-quality genomic single-nucleotide polymorphisms (SNPs) by sequencing the genomes and 702 amplicon sequence variants (ASVs) of the gut microbiome by sequencing the 16S rRNA gene, both of which were used for analyses of linear mixed models.