Publications by authors named "C Psoinos"
Background: Ripretinib, a broad-spectrum KIT and platelet-derived growth factor receptor A switch-control tyrosine kinase inhibitor, is approved for the treatment of adult patients with advanced gastrointestinal stromal tumor as ≥ fourth-line therapy. We present the efficacy and safety of ripretinib in patients with KIT-altered metastatic melanoma enrolled in the expansion phase of the ripretinib phase I study.
Patients And Methods: Patients with KIT-altered metastatic melanoma were enrolled and treated with ripretinib at the recommended phase II dose of 150 mg once daily in 28-day cycles.
Acute Appendicitis after Liver Transplantation: A Case Report and Review of the Literature.
Int J Organ Transplant Med
November 2017
Acute appendicitis is one of the most common etiologies for acute abdomen. However, fewer than 30 cases of acute appendicitis after liver transplantation have so far been reported in the literature. Previous case studies have concluded that acute appendicitis after liver transplantation may present differently than in non-immunosuppressed patients and thus may lead to more complications.
View Article and Find Full Text PDFBackground: C. difficile (CDI) has surpassed methicillin-resistant staph aureus as the most common nosocomial infection with recurrence reaching 30% and the elderly being disproportionately affected. We hypothesized that post-discharge antibiotic therapy for continued CDI treatment reduces readmissions.
View Article and Find Full Text PDFObjective: To determine the effect of aeromedical transport on trauma mortality when accounting for geographic factors.
Background: The existing literature on the mortality benefit of aeromedical transport on trauma mortality is controversial. Studies examining patient and injury characteristics find higher mortality, whereas studies measuring injury severity find a protective effect.
Article Synopsis
- Advances in critical care are changing death patterns in trauma patients, prompting a study on mortality rates of those who survive their initial hospitalization.
- A retrospective analysis of a Level-1 trauma center showed that, out of 1,695 critically injured patients, 67% were discharged alive, with 86% of those still alive two years later; however, nearly half of those who died did so within the first year post-discharge.
- Factors such as longer hospital and ICU stays, the need for specific medical procedures, and demographic variables like age and gender were linked to higher mortality rates, suggesting that patients with extended ICU stays may need more thorough post-discharge care discussions.