Clear evidence that long-term, low-dose tamoxifen treatment can induce ocular toxicity. A prospective study of 63 patients.

The current study has prospectively investigated the incidence and course of ocular toxicity after low-dose tamoxifen treatment. Sixty-three patients with cancer who could be examined were analyzed. Tamoxifen was administered on a 20-mg daily dose.

[Evaluation of clinical symptoms and laboratory data as diagnostic criteria for Sjögren's syndrome].

In this study the authors evaluated the sensitivity, specificity and misclassification error rate of the following parameters: subjective xerophthalmia (questionnaire), positive Schirmer's I test less than or equal to 5 mm/5 min, positive rose-bengal staining on slit lamp examination, subjective xerostomia (questionnaire), abnormal stimulated parotid flow rate less than or equal to 0.5 ml/5 min and recurrent parotid gland enlargement. Thirty-two patients with primary SS (pSS), 40 patients with some of the criteria for pSS, 20 patients with SS in association with RA (sSS), 45 patients with RA and some of SS criteria and 29 RA patients without any clinical or histological manifestations of SS participated in this study.