Metallo-azapeptides: Controlled Metal Chelation to Peptide Backbone Nitrogen.

We present the first approach to controlled metal chelation of peptide backbones, where the anchoring site is an aza-amino acid nitrogen and the directionality of chelation events is dictated by the acidity of neighboring NHs. Selective backbone chelation precludes the need for metal-binding side chains and/or free - or -termini in peptides. We show that the presence and location of an aza-amino acid impact complex formation and report the first X-ray crystal structures of azapeptides bound to palladium and nickel.

Immediate effect of alone and combined virtual reality, gait-like muscle vibration and transcranial direct current stimulation on neuropathic pain after spinal cord injury: a pilot study.

Study Design: Quasi-experimental pilot study.

Objectives: Evaluate the immediate effect of virtual reality (VR), gait-like muscle vibration (MV) and transcranial direct current stimulation (tDCS) combined or alone on neuropathic pain in individuals with spinal cord injury (SCI).

Setting: Inpatient rehabilitation centre.

Effects of gene dosage on cognitive ability: A function-based association study across brain and non-brain processes.

Copy-number variants (CNVs) that increase the risk for neurodevelopmental disorders also affect cognitive ability. However, such CNVs remain challenging to study due to their scarcity, limiting our understanding of gene-dosage-sensitive biological processes linked to cognitive ability. We performed a genome-wide association study (GWAS) in 258,292 individuals, which identified-for the first time-a duplication at 2q12.

Changes in self-confidence in professional, personal, and scientific skills by gender during physician-scientist training at the University of Pittsburgh.

Introduction: Persistence in physician-scientist careers has been suboptimal, particularly among women. There is a gender gap in self-confidence in medicine. We measured the impact of our physician-scientist training programs on trainee's confidence in professional, personal, and scientific competencies, using a survey measuring self-rated confidence in 36 competencies across two timepoints.

Early-life socioeconomic position and later-life cognitive functioning: A meta-analysis.

Objectives: This meta-analysis aimed to quantify the association between childhood SEP and later-life cognitive functioning and identify possible moderators.

Method: We conducted random-effects meta-analyses of 39 reports, contributing 49 independent subsamples from 229,824 respondents. Moderators were analyzed using meta-regression and subgroup analyses.