A cysteine-rich domain of the Cuf1 transcription factor is required for high copper stress sensing and fungal virulence.

Unlabelled: The ability to sense, import but also detoxify copper (Cu) has been shown to be crucial for microbial pathogens to survive within the host. Previous studies conducted with the opportunistic human fungal pathogen ( ) have revealed two extreme Cu environments encountered during infection: A high Cu environment within the lung and a low Cu environment within the brain. However, how senses these different host Cu microenvironments, and the consequences of a blunted Cu stress adaption for pathogenesis, are not well understood.

[Tobacco use : guidelines for primary care physicians].

Tobacco use affects about 25% of the population and is the most important modifiable risk factor for many diseases, namely cancers, cardiovascular and pulmonary diseases. The role of the primary care physician is essential in providing screening and brief intervention to all patients, particularly to those at higher risk. This will help them to quit smoking, or adopt risk reduction strategies, according to their own wish.

[Diagnosing and treating acute and chronic dizziness : new approach in 2024].

Diagnosing and treating acute and chronic dizziness is challenging for general physicians with multiple potential etiologies and difficulties in diagnosis. A new classification of dizziness is meant to facilitate diagnosis and treatment, based on the trigger and the timing of dizziness, rather than the quality. The latter is not consi-dered as a reliable information anymore for diagnosis.