Publications by authors named "C Presne"
Polyomaviruses BK (BKPyV) and JC (JCPyV), belonging to the Polyomaviridae, are responsible for human pathologies. In kidney transplant recipients, BKPyV replication can lead to irreversible nephron damage whereas JCPyV replication remains asymptomatic. Concomitant replication is rare and potential competition between the infections has been described.
View Article and Find Full Text PDFBackground/objectives: In the absence of an effective antiviral treatment for BK polyomavirus (BKPyV), a better understanding of the epidemiology and time course of BKPyV replication after kidney transplantation is needed to limit the virus's impact on the graft outcome.
Methods: In a 7-year study, we screened more than 430 kidney transplant recipients and analyzed the time course and virological characteristics of BKPyV replication.
Results: Urinary viral replication was observed in 116 (27%) of the 430 patients, and 90 of the 116 (78%) had viral DNAemia.
Article Synopsis
- Kidney transplant recipients (KTRs) show a weak humoral response to COVID-19 vaccines, and the specific factors affecting this response to three vaccine doses are still unclear.
- A study at Amiens University Hospital analyzed KTRs and found that 66.3% were seropositive while only 26.1% had an optimal antibody response; seropositivity was strongly linked to a history of COVID-19.
- Significant non-response factors included being female, time since transplant, higher creatinine levels, and specific immunosuppressive medications.
Article Synopsis
- The study examines the prevalence and predictors of cerebral lesions in patients with immune thrombotic thrombocytopenic purpura (iTTP) and hemolytic uremic syndrome (HUS) during their acute phases.
- One-third of the 73 patients analyzed showed acute ischemic lesions on MRI, and neurological symptoms were not significantly different between iTTP and HUS cases.
- Key factors predicting these lesions included the presence of old infarcts, elevated blood pulse pressure, and a diagnosis of iTTP, indicating potential areas for enhanced treatment approaches.*
Article Synopsis
- Thrombotic thrombocytopenic purpura (iTTP) and atypical hemolytic-uremic syndrome (aHUS) can lead to long-term mental health issues, like anxiety and PTSD, even after patients achieve remission.
- In a study of 103 patients, 50% showed anxiety symptoms while 27% exhibited PTSD, with no significant differences between the iTTP and aHUS groups.
- The quality of life was notably worse in patients with PTSD symptoms, and factors like male sex and severe acute platelet counts were linked to higher PTSD prevalence, highlighting the need for regular mental health screenings in affected individuals.