CRTH2 is not involved in the anti-enteropooling effect of PGD2 in the small intestine.

The majority of prostaglandins (PGs) are known to induce intestinal fluid secretion (enteropooling). In contrast, PGD(2) has been demonstrated to inhibit fluid secretion induced by other PGs. This study was aimed to investigate, by the use of selective agonists/antagonists, which type of PGD(2) receptor mediates this inhibitory effect.

Effects of the cyclooxygenase-2 inhibitor NS-398 on thromboxane and leukotriene synthesis in rat peritoneal cells.

Objective: Inhibition of inducible cyclooxygenase (COX)-2 has been suggested to offer therapeutic advantages without some side effects associated with the inhibition of constitutive COX activity. These side effects encompass asthmatic responses that can be induced by analgesic/ antiphlogistic drugs and are possibly related to increased leukotriene (LT) biosynthesis. We have therefore investigated whether or not the selective COX-2 inhibitor NS-398, similar to indomethacin, stimulates leukotriene (LT) biosynthesis in rat peritoneal cells.