Publications by authors named "C Prata"
Article Synopsis
- Duchenne muscular dystrophy (DMD) is a muscle-wasting disease that requires additional supportive therapies alongside gene treatments to improve patients' quality of life.
- Plumbagin, a natural compound similar to vitamin K3, has shown promise in reducing chronic inflammation and improving muscle function in studies conducted on dystrophic fruit flies and mdx mice.
- The research found that plumbagin enhanced muscle performance and morphology while activating specific pathways to reduce oxidative stress and inflammation, suggesting potential for further exploration as a human therapy.
Benznidazole (BNZ) serves as the primary drug for treating Chagas Disease and is listed in the WHO Model List of Essential Medicines for Children. Herein, a new child-friendly oral BNZ delivery platform is developed in the form of supramolecular eutectogels (EGs). EGs address BNZ's poor oral bioavailability and provide a flexible twice-daily dose in stick-pack format.
View Article and Find Full Text PDFBackground: Isolated limb hyperthermic-antiblastic perfusion (ILP) was the most effective local treatment for advanced in-transit melanoma, but the advent of modern effective immunotherapy (IT), such as immune checkpoint inhibitors, has changed the treatment landscape.
Methods: This study evaluated the role of the association between ILP and IT in the treatment of locally advanced unresectable melanoma, particularly in relation to modern systemic therapies. We analyzed 187 consecutive patients who were treated with ILP (melphalan or melphalan associated with TNF-alpha) for advanced melanoma at the Veneto Institute of Oncology of Padua (Italy) and the Padua University Hospital (Italy) between June 1989 and September 2021.
Empathy is a crucial component to infer and understand others' emotions. However, a synthesis of studies regarding empathy and its neuronal correlates in perceptual tasks using event-related potentials (ERPs) has yet to occur. The current systematic review aimed to provide that overview.
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