A dipyrrole derivative from inhibits an anti-diabetic drug target Dipeptidyl Peptidase (DPP)-IV .

, a succulent herb, has a long history of use in traditional medicine, including diabetes. Earlier studies from our laboratory demonstrated that the extract has the ability to inhibit the diabetic drug target dipeptidyl peptidase (DPP) IV . This current study focuses on the isolation of small water soluble active molecule(s) involved in DPP-IV inhibition from extract, and further to characterize its structure and to elucidate the mode of inhibition of the DPP-IV enzyme.