Publications by authors named "C Pozzoli"
Article Synopsis
- Sulforaphane, derived from glucoraphanin found in broccoli sprouts, shows significant anti-inflammatory effects in a study with intestinal cells, while glucoraphanin itself appears inactive in this context.
- In celiac disease, persistent inflammation and oxidative stress affect the small intestine, making it crucial to explore compounds that could alleviate these conditions.
- The study indicates that sulforaphane modulates inflammatory responses and epithelial integrity during inflammatory conditions, suggesting glucoraphanin may also have more to offer than previously thought.
Mill. () processing and pruning generate several by-products, including leaves, burs, and shells (inner and outer teguments), which are considered an important source of high-value phytochemicals. Ellagitannins from leaf extracts have been described to impair viability and inflammation in gastric cells.
View Article and Find Full Text PDFArticle Synopsis
- Pigmented corn varieties are gaining attention for their health benefits, particularly their polyphenolic content, making them suitable for individuals with celiac disease who require gluten-free diets.
- The study analyzed the phenolic composition of two Italian pigmented corn varieties using HPLC-DAD, noting the presence of phenolic acids and anthocyanins, with minimal changes post-digestion.
- Results showed that extracts from these corns reduced inflammation markers in human intestinal cells and reversed oxidative stress effects, suggesting potential benefits for managing celiac disease inflammation through a gluten-free diet.
Khat leaves, indigenous to eastern Africa, have been chewed for centuries for their stimulant effects, attributed to alkaloids such as cathinone and cathine. Although associated with gastric disorders like gastritis and gastro-oesophageal reflux disease, the underlying molecular mechanisms remain unclear. This study aimed to examine the morpho-anatomy of khat leaves using light microscopy and histochemistry and to assess the effects of leaf extracts and alkaloids on human gastric epithelial cells (GES-1).
View Article and Find Full Text PDFArticle Synopsis
- Acne vulgaris is a common skin condition in young people, characterized by inflammation and the buildup of skin cells, and is influenced by bacterial colonization.
- The study investigated the anti-acne effects of chestnut leaf extract and a specific compound, castalagin, both derived from ellagitannins, finding they effectively inhibited pro-inflammatory cytokines (IL-8 and IL-6) in skin cells at low concentrations while also reducing bacterial biofilm formation.
- This research is significant as it’s the first to highlight the potential of ellagitannins in acne treatment, hinting at future development of chestnut-based therapies subject to further testing in living organisms.