We present the design of a VMI spectrometer optimized for attosecond spectroscopy in the 0-40 eV energy range. It is based on a compact three-electrode configuration where the lens shape, size, and material have been optimized using numerical simulations to improve the spectral resolution by a factor of ∼5 relative to the initial design [Eppink and Parker, Rev. Sci.
View Article and Find Full Text PDFThe major economic and health consequences of COVID-19 called for various protective measures and mass vaccination campaigns. A previsional model was used to predict the future impacts of various measure combinations on COVID-19 mortality over a 400-day period in France. Calibrated on previous national hospitalization and mortality data, an agent-based epidemiological model was used to predict individual and combined effects of booster doses, vaccination of refractory adults, and vaccination of children, according to infection severity, immunity waning, and graded non-pharmaceutical interventions (NPIs).
View Article and Find Full Text PDFThe outbreak of the SARS-CoV-2 virus, enhanced by rapid spreads of variants, has caused a major international health crisis, with serious public health and economic consequences. An agent-based model was designed to simulate the evolution of the epidemic in France over 2021 and the first six months of 2022. The study compares the efficiencies of four theoretical vaccination campaigns (over 6, 9, 12, and 18 months), combined with various non-pharmaceutical interventions.
View Article and Find Full Text PDFTriplet action spectra of two similar copper porphyrins, copper tetraphenylporphyrin (CuTPP) and copper octaethylporphyrin (CuOEP), have been studied in the gas phase at low temperatures in the absence of external perturbations by using a resonant pump and a 193 nm probe, ionizing the ππ orbital localized on the porphyrin cycle. The molecules were prepared by laser desorption in a disk source, then cooled in a helium supersonic expansion, and finally excited in the Q band system (S ← S). This type of experiment allows the spectroscopic characterization of large non-luminescent molecules in the absence of solvent perturbations.
View Article and Find Full Text PDF1. We have applied the concept of using MBIs to produce CYP-Silensomes to quantify the contribution of the major CYPs to drug metabolism (fmCYP). 2.
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