Publications by authors named "C Poremba"
Aim: We aimed to evaluate the applicability of a customized NanoString panel for molecular subtyping of recurrent or metastatic head and neck squamous cell carcinoma (R/M-HNSCC). Additionally, histological analyses were conducted, correlated with the molecular subtypes and tested for their prognostic value.
Material And Methods: We conducted molecular subtyping of R/M-HNSCC according to the molecular subtypes defined by Keck et al.
Article Synopsis
- Advances in the molecular characterization of endometrial endometrioid adenocarcinomas have improved prognostic stratification but identifying risks in microsatellite instability (MSI) and copy-number (CN)-low cases remains difficult.
- The study analyzed histomorphologic parameters in resection specimens from 228 tumors to discover potential biomarkers for better prognosis assessment.
- Key findings included tumor budding (TB) being a significant independent factor for MSI tumors, while WHO grading was crucial for CN-low tumors, suggesting both should be used for improved management of these cancer cases.
Background: The prognostic significance of tumour budding (TB) and minimal cell nest size (MCNS) was shown in human papillomavirus (HPV)-negative head and neck squamous cell carcinomas (HNSCC). However, the optimisation of cutpoints, the prognostic impact in HPV-positive HNSCC, and the comparison with other histopathological grading systems are insufficiently investigated.
Methods: TB and MCNS were analysed digitally in 1 and 10 high-power fields (HPF) of 331 HPV-positive and HPV-negative cases from TCGA.
Background: Substance use disorder (SUD) during pregnancy requires efficacious interventions based on understanding the ebb and flow of risk and protective factors for substance use across time. To assess how these fluctuations are associated temporally with substance use, we used ecological momentary assessment (EMA) to evaluate substance use risk (posttraumatic stress disorder [PTSD] symptoms) and protective (prenatal fetal bonding) factors and their associations with prenatal substance use recorded in real time.
Methods: Pregnant women in SUD treatment (N = 33) with prior trauma exposure received smartphones with an EMA application that queried them thrice daily for 28 days about PTSD symptoms, prenatal bonding, and substance use.