Publications by authors named "C Pook"
Malnutrition affects over 30 million children annually and has profound immediate and enduring repercussions. Survivors often suffer lasting neurocognitive consequences that impact academic performance and socioeconomic outcomes. Mechanistic understanding of the emergence of these consequences is poorly understood.
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- Sleep Related Painful Erections (SRPE) are REM sleep parasomnias that can severely affect sleep quality and daily functioning, prompting the development of a specialized diagnostic and treatment pathway.
- Diagnostic measures included a thorough review of patient history, clinical examinations, and various tests to identify other causes of penile pain, leading to a structured approach that involved medications, sleep studies, and pelvic floor therapy.
- Out of 20 patients treated, 70.6% experienced symptom relief, with significant improvements seen in sleep quality and pelvic floor assessments, highlighting the effectiveness of this comprehensive management plan.
Kawakawa () is an endemic medicinal plant widely consumed by Māori in New Zealand. Presence of diverse biologically active phytochemicals in kawakawa may underpin its putative therapeutic anti-inflammatory properties. However, no human studies on its anti-inflammatory effects are yet undertaken.
View Article and Find Full Text PDFIntroduction: Accurately identifying and quantifying polar metabolites using untargeted metabolomics has proven challenging in comparison to mid to non-polar metabolites. Hydrophilic interaction chromatography and gas chromatography-mass spectrometry are predominantly used to target polar metabolites.
Objectives: This study aims to demonstrate a simple one-step extraction combined with liquid chromatography-mass spectrometry (LC-MS) that reliably retains polar metabolites.
Article Synopsis
- Piper excelsum (kawakawa) has been used therapeutically by Māori in New Zealand and is now popular as a beverage and functional food ingredient, with this study focusing on how its chemicals are metabolized and excreted by humans.* -
- Two studies were conducted: one with six male volunteers to assess the bioavailability of kawakawa tea metabolites and another with 30 volunteers to explore its impact on glucose metabolism, revealing 26 significant urinary metabolites linked to kawakawa tea consumption.* -
- The findings indicate that various kawakawa compounds are bioavailable, undergoing metabolic changes in the body, with some metabolites being associated with specific components of the tea.*