Publications by authors named "C Platt"
Article Synopsis
- IgA vasculitis (IgAV) is a common type of blood vessel disease in kids, and while most get better, some can have long-term kidney problems.
- A group of 28 experts worked for over a year to create guidelines on how to treat IgAV and its complications by reviewing many studies and getting feedback from others.
- The new guidelines have been approved by important health organizations and aim to help doctors provide better care for kids with this condition.
Article Synopsis
- A 1-month-old baby was very sick with a fever and needed help because his body was losing too much water.
- Doctors found that his blood had too much salt and other problems, suggesting he might have a type of diabetes insipidus.
- After tests, they discovered a genetic issue making it hard for his body to use a hormone called AVP, leading to a diagnosis of AVP resistance, not a lack of it.
Genetic testing in nephrotic syndrome may identify heterozygous predicted-pathogenic variants (HPPVs) in autosomal recessive (AR) genes that are known to cause disease in the homozygous or compound heterozygous state. In such cases, it can be difficult to define the variant's true significance and questions remain about whether a second pathogenic variant has been missed during analysis or whether the variant is an incidental finding. There are now known to be over 70 genes associated with nephrotic syndrome, the majority inherited as an AR trait.
View Article and Find Full Text PDFBackground: The health and well-being of children in foster care are of high concern. A resource with which to disrupt maladaptation and promote healing are positive relationships among children and caregivers within the foster home. The research question was: Can an online intervention improve family hardiness and sibling relationships within foster care families?
Objectives: To: (1) establish feasibility and acceptability of an online behavioral intervention within the foster family, (2) explore the effects of the intervention on relational quality outcomes, and (3) decompose the mechanisms driving improved family hardiness through mediation analysis.
There are approximately 500 congenital disorders that impair immune cell development and/or function. Patients with these disorders may present with a wide range of symptoms, including increased susceptibility to infection, autoimmunity, autoinflammation, lymphoproliferation, and/or atopy. Flow cytometry-based immune phenotyping of T and B lymphocytes plays an essential role in the evaluation of patients with these presentations.
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