Publications by authors named "C Platen"
The main objective of this project was to compare in the field conditions two strategies of re-nutrition of children with moderate acute malnutrition (MAM) aged from 6 to 24 months, targeting the microbiota in comparison with a standard regimen. A three-arm, open-label, pragmatic randomised trial was conducted in four countries (Niger, CAR, Senegal and Madagascar). Children received for 12 weeks either fortified blended flour (FBF control) = arm 1, or FBF + azithromycin (oral suspension of 20 mg/kg/day daily given with a syringe) for the first 3 days at inclusion = arm 2 or mix FBF with inulin/fructo-oligosaccharides (6 g/day if age ≥12 months and 4 g if age <12 months) = arm 3.
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- Amphiregulin (AREG) is a key ligand for the epidermal growth factor receptor (EGFR) that affects monocyte-induced cell death and T-cell responses in peripheral blood.
- The study found that AREG reduces T-cell proliferation during stimulation and down-regulates costimulatory molecules on monocytes, indicating its role in modulating immune responses.
- Additionally, AREG influences T-cell polarization, leading to an increase in IL-17-producing T cells, while maintaining the regulatory T cell proportion.
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- Magnetic induction measurement (MIM) is a noninvasive technique used to monitor breathing in newborn piglets by placing measurement coils in their incubators, which helps in identifying acute pulmonary issues that might affect neurological development in preterm infants.
- In a study involving 11 piglets, MIM successfully detected most ventilation disorders like apnea and pneumothorax, showing significant changes in magnetic induction, whereas aspiration was not detected.
- The findings suggest that MIM could be beneficial for early detection of respiratory problems in newborns, potentially leading to timely therapeutic interventions, but the effectiveness is influenced by the placement of the measurement coils.
Neonates are extremely susceptible to bacterial infections, and evidences suggest that phagocytosis-induced cell death (PICD) is less frequently triggered in neonatal monocytes than in monocytes from adult donors. An insufficient termination of the inflammatory response, leading to a prolonged survival of neonatal monocytes with ongoing proinflammatory cytokine release, could be associated with the progression of various inflammatory diseases in neonates. Our previous data indicate that amphiregulin (AREG) is increasingly expressed on the cell surface of neonatal monocytes, resulting in remarkably higher soluble AREG levels after proteolytic shedding.
View Article and Find Full Text PDFCleaving ligands and receptors of the tumor necrosis factor (TNF) superfamily can critically regulate the induction of apoptosis. Matrix metalloproteinases (MMPs) such as MMP-9 and tumor necrosis factor-α-converting enzyme (TACE) have been shown to cleave CD95-Ligand (CD95L) and TNF/(TNF receptor-1) TNFR1 which induce phagocytosis induced cell death (PICD) in adult monocytes. This process is reduced in neonatal monocytes.
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