Publications by authors named "C Plaisier"
Article Synopsis
- Single-cell transcriptomics reveals diverse cellular behavior, with a focus on the importance of cell cycle stages in human neural stem cells.
- The ccAFv2 classifier categorizes cells into six distinct cell cycle states and a quiescent-like state, outperforming existing methods while offering flexibility and customizable classifications.
- Demonstrated effectiveness across different cell types and species, ccAFv2 is accessible as an R package and a Python package, making it a valuable resource for analyzing complex biological data and understanding cellular dynamics.
Atherosclerosis, a chronic inflammatory disease, is the primary cause of myocardial infarction and ischemic stroke. Recent studies have demonstrated that dysregulation of yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding domain (TAZ) contributes to plaque development, making YAP/TAZ potential therapeutic targets. However, systemic modulation of YAP/TAZ expression or activities risks serious off-target effects, limiting clinical applicability.
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- MRI is commonly used in high-grade glioma treatments to map tumor boundaries and assist in surgery, revealing important tumor biology through its measurements.
- The study found that specific MRI techniques (like T1+C) not only visualize the tumor's blood flow disruption but also indicate immune cell infiltration, enhancing our understanding of how these factors interact within the tumor environment.
- The research offers a new, unbiased methodology for linking MRI results with tumor biology, laying the groundwork for future advancements in noninvasive diagnostics and treatment strategies for patients with high-grade gliomas.
Sampling restrictions have hindered the comprehensive study of invasive non-enhancing (NE) high-grade glioma (HGG) cell populations driving tumor progression. Here, we present an integrated multi-omic analysis of spatially matched molecular and multi-parametric magnetic resonance imaging (MRI) profiling across 313 multi-regional tumor biopsies, including 111 from the NE, across 68 HGG patients. Whole exome and RNA sequencing uncover unique genomic alterations to unresectable invasive NE tumor, including subclonal events, which inform genomic models predictive of geographic evolution.
View Article and Find Full Text PDFTriple-negative breast cancer (TNBC) represents around 15% of the 2.26 million breast cancers diagnosed worldwide annually and has the worst outcome. Despite recent therapeutic advances, there remains a lack of targeted therapies for this breast cancer subtype.
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