Publications by authors named "C Placidi"
Article Synopsis
- The FP7 Sanowork project aimed to reduce risks associated with engineered nanomaterials (ENM) by modifying their surfaces to prevent health issues, focusing on zirconium (ZrO2) and titanium (TiO2) nanoparticles.
- The study evaluated the cytotoxicity and genotoxicity of these nanoparticles in both their uncoated and modified forms, using various in vitro assays on a specific mouse cell line (Balb/3T3).
- Results indicated that surface modifications (like with citrate) did not effectively reduce harmful effects, and in some cases, increased toxicity, highlighting the need for thorough testing of potential long-term impacts.
Lipases play various roles in fat digestion, lipoprotein metabolism, and in the mobilization of fat stored in lipid bodies in animals, plants and microorganisms. In association with these physiological functions, there is an important field of research for discovering lipase inhibitors and developing new treatments of diseases such as obesity, atherosclerosis, diabetes and tuberculosis. In this context, the development of convenient, specific and sensitive analytical methods for the detection and assay of lipases and/or lipase inhibitors is of major importance.
View Article and Find Full Text PDFThe Hearts and Minds of Ghana project improves the lives of those who are less fortunate and have few resources. Providing clear goals for the mission, devising prior guidelines for patient selection and treatment, achieving a better understanding of local culture and expectations, and good team work, facilitate making better ethical decisions, but doesn't make them less difficult.
View Article and Find Full Text PDFArticle Synopsis
- Type 2 diabetes is characterized by insulin resistance, decreased β-cell mass, and increased α-cell mass, impacting insulin signaling and cell-cycle control in islet cells.
- Research using human pancreas samples and a mouse model showed that reduced β-cell mass in diabetes correlates with impaired cell-cycle progression and altered expression of key proteins involved in growth regulation.
- Enhancing insulin signaling and understanding pathways involving proteins like FoxO1 may offer new therapeutic strategies to promote β-cell regeneration in the treatment of Type 2 diabetes.
Objectives: Serotonin-producing tumors of the pancreas are rare endocrine neoplasms composed of enterochromaffin (EC) cells that have been mainly described in the literature as case reports. This study analyzes the clinicopathologic features of a series of pancreatic EC cell neoplasms and their similarities to and differences from intestinal EC cell tumors.
Methods: The morphological, immunohistochemical, ultrastructural, and fluorescent in situ hybridization features of 15 pancreatic and 20 intestinal serotonin-producing neoplasms were compared.