Publications by authors named "C Pizzocolo"
Background: In developing countries, malnutrition is a contributing factor in over 50% of child deaths. Mortality rates are higher in underweight children, and HIV-infection is known to increase underweight. Our goals were to evaluate the prevalence of HIV among children hospitalised for severe malnutrition (SM) at the Niamey national hospital (Niger), and to compare renutrition and mortality by HIV-status.
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- In sub-Saharan Africa, access to biological measurements for monitoring patients on antiretroviral therapy (ART) remains limited, complicating treatment management.
- In a study of 865 patients in Segou, Mali, only 40 switched to second-line ART, indicating a low switch rate of 3.3 switches per 100 person-years, primarily due to treatment failure or severe intolerance.
- The switches occurred earlier due to intolerance rather than treatment failure, suggesting physicians might be hesitant to change ART regimens due to limited options, despite a higher expected rate of failure.
Article Synopsis
- The study aimed to analyze HIV-1 variants in Mali and assess drug resistance transmission rates in 2006.
- In a group of 198 newly diagnosed patients, the predominant HIV-1 subtype was CRF02_AG (72%), but genetic diversity had increased since 2005.
- The overall primary resistance prevalence was found to be low at 11.5%, indicating a need for ongoing monitoring given the rise in antiretroviral drug use.