Publications by authors named "C Pirazzi"
Article Synopsis
- - The study aimed to assess the prevalence of atherosclerosis in coronary and carotid arteries among individuals with prediabetes and diabetes compared to those without diabetes, involving over 30,000 participants aged 50-64.
- - The findings revealed that participants with prediabetes or diabetes had significantly higher levels of coronary artery plaque, stenosis, and calcium scores compared to normoglycaemic individuals, indicating a greater cardiovascular risk.
- - Notably, the prevalence of coronary atherosclerosis was highest in those with known diabetes, while both prediabetic and diabetic participants showed increased plaque in carotid arteries compared to normoglycaemic individuals.
Inter- and intra-observer variability in the echocardiographic evaluation of wall motion abnormality in patients with ST-elevation myocardial infarction or takotsubo syndrome - A novel approach.
Echocardiography
July 2023
Article Synopsis
- The study aimed to improve the assessment of left ventricular wall motion abnormalities (WMAs) by introducing new measurement methods and comparing them to traditional scoring indices like the wall motion score index (WMSI).
- Researchers analyzed 140 echocardiograms from patients with serious heart issues, focusing on various metrics for measuring wall motion, including the percentage of akinesia and hypokinesia.
- Results showed that the new methods demonstrated low inter- and intra-observer variability, making them reliable alternatives for evaluating WMAs in echocardiographic exams.
Background: Inflammation is a key driver of heart failure with preserved left ventricular ejection fraction. AZD4831 inhibits extracellular myeloperoxidase, decreases inflammation, and improves microvascular function in preclinical disease models.
Methods And Results: In this double-blind phase 2a study (Safety and Tolerability Study of AZD4831 in Patients With Heart Failure [SATELLITE]; NCT03756285), patients with symptomatic heart failure, left ventricular ejection fraction of ≥40%, and elevated B-type natriuretic peptides were randomized 2:1 to once-daily oral AZD4831 5 mg or placebo for 90 days.
Article Synopsis
- The study compares ECG changes over 30 days between female patients with anterior STEMI (a type of heart attack) and female patients with Takotsubo syndrome (a stress-induced heart condition).
- It found that T wave inversion patterns were similar in both groups, but ST elevation was more common in STEMI, while QT prolongation was less frequent.
- Overall, the ECG patterns suggest that TTS may show a temporary ischemic-like pattern, indicating similarities in heart stress responses between these conditions.
Background: Bilberries from Sweden, rich in polyphenols, have shown cholesterol-lowering effects in small studies, and the cholesterol-lowering properties of oats, with abundant beta-glucans and potentially bioactive phytochemicals, are well established. Both may provide cardiometabolic benefits following acute myocardial infarction (AMI), but large studies of adequate statistical power and appropriate duration are needed to confirm clinically relevant treatment effects. No previous study has evaluated the potential additive or synergistic effects of bilberry combined with oats on cardiometabolic risk factors.
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