IL-1beta mediates MMP secretion and IL-1beta neosynthesis via upregulation of p22(phox) and NOX4 activity in human articular chondrocytes.

Objectives: Osteoarthritis (OA) is characterized by a progressive alteration of the biochemical properties of the articular cartilage. Inflammation plays a major role in OA, particularly through the cytokine Interleukine-1β, promoting reactive oxygen species (ROS) generation and matrix metalloproteinases (MMP) synthesis by the chondrocytes, orchestrating matrix proteolysis. NADPH oxidases (NOX) are membrane enzymes dedicated to the production of ROS.

Cognitive structures of obese patients undergoing bariatric surgery: a concept mapping analysis.

Background: The preparation of patients for bariatric surgery includes education concerning the intervention and its after-effects, and training on the health behaviors that they must put into practice after surgery. In this descriptive study, we have analyzed the cognitive structures of obese patients who have participated in a series of education sessions given by a medical team.

Methods: 30 severely obese patients participated in an interview during which a concept map was drawn up.

[Implementation of therapeutic education programmes for patients living with HIV in four low-income countries: an evaluative approach].

This study focuses on the evaluation of conditions for implementation of therapeutic education (TE) programmes for patients living with HIV in seven health care structures located in four low and middle income countries (Morocco, Senegal, Congo and Cambodia). The objectives were the following: to identify how TE was integrated in health care practice within the various contexts, to assess the quality of educational process and to identify the contributing factors which favour the sustainability of TE programmes. The evaluation methodology is based on quality criteria and indicators for TE programmes.

The use of concept mapping to enlighten the knowledge networks of diabetic children: a pilot study.

Objective: The value of concept mapping in enlightening nature and organization of knowledge was shown with adult diabetic or obese patients. Our objectives were to ascertain the relevance and feasability of concept mapping in diabetic children during an educational program.

Method: This qualitative research was performed in 5 children from 8 to 13 years.

[Evaluation of professional development of Cambodian male nurses specializing in anesthesia and intensive care, trained through humanitarian care programs].

Objectives: To assess the working conditions of Cambodian male nurses specialised in anaesthesia and intensive care (NSAIs), degree of satisfaction, whether training was suited to the Cambodian needs and practical application of training.

Study Design: Prospective survey.

Persons: Two training years including 30 NSAIs.