Publications by authors named "C Pinheiro"
Article Synopsis
- The study focused on identifying key immune molecules for diagnosing S. stercoralis infections using serum samples tested with specific antigens (AgS and AgM).
- Results from IgG-ELISA showed decent sensitivity (82.3 to 85.3%) and varying specificity (60.0 to 93.3%), but some cross-reactivity with other helminth infections was noted.
- A specific 140 kDa protein from AgS demonstrated perfect sensitivity and specificity without cross-reactivity, indicating its potential for creating reliable immunodiagnostic tests for strongyloidiasis.
Increased ROS levels, antioxidant defense disturbances and bioenergetic disruption induced by thiosulfate administration in the brain of neonatal rats.
Metab Brain Dis
December 2024
Sulfite oxidase deficiencies, either caused by deficiency of the apoenzyme or the molybdenum cofactor, and ethylmalonic encephalopathy are inherited disorders that impact sulfur metabolism. These patients present with severe neurodeterioration accompanied by cerebral cortex and cerebellum abnormalities, and high thiosulfate levels in plasma and tissues, including the brain. We aimed to clarify the mechanisms of such abnormalities, so we assessed the ex vivo effects of thiosulfate administration on energetic status and oxidative stress markers in cortical and cerebellar tissues of newborn rats.
View Article and Find Full Text PDFProtective effects of the PPAR agonist bezafibrate against disruption of redox and energy homeostasis, neuronal death, astroglial reactivity, and neuroinflammation induced in vivo by D-2-hydroxyglutaric acid in rat brain.
Eur J Pharmacol
December 2024
The biochemical hallmark of D-2-hydroxyglutaric aciduria is brain accumulation of D-2-hydroxyglutaric acid (D2HG). Patients present predominantly neurological manifestations, whose pathogenesis is still unknown. Thus, we examined the impact of elevated brain levels of D2HG, induced by intracerebral injection of this metabolite in juvenile rats, on redox and mitochondrial homeostasis and histochemical landmarks in the cerebral cortex.
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- Cigarette butts (CBs) are significant pollutants, and this study investigates their effects on Artemia franciscana in different temperature conditions, highlighting the environmental challenges they pose.
- The research included acute and sub-chronic exposure tests to assess toxicity levels of smoked and non-smoked cigarette butts at temperatures of 25°C and 30°C.
- Findings revealed that higher temperatures increased toxicity, disrupting crucial biological functions like enzyme activity and promoting oxidative damage, underscoring the need to address CB pollution in the context of climate change.
Organic electrochromic polymers hold great potential for integration into low-power flexible electrochromic displays (F-ECDs) due to their wide range of colors and simple processing. However, challenges such as inefficient charge transfer and degradation upon device integration hinder their practical applications. Herein, we report an innovative, general approach that utilizes template-induced supramolecular nanostructuring to engineer established electrochromic polymers, enhancing their performance and durability.
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