Publications by authors named "C Pierli"

Article Synopsis
  • Transcatheter aortic valve implantation (TAVI) has transformed how patients with severe aortic stenosis are treated, becoming the go-to option for those who can't undergo surgery and preferred for higher-risk patients.
  • Advances in technology and experience have led to an updated position paper by the Italian Society of Interventional Cardiology on TAVI practices.
  • The document aims to guide institutions and operators in evaluating their ability to effectively launch and sustain a TAVI program.
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Despite the technical advancements in transcatheter aortic valve implantation (TAVI), this procedure in patients with peripheral artery disease remains challenging and requires a patient-tailored management by the Heart Team. In-depth assessment of the patient's vascular anatomy is of utmost importance for the management of TAVI procedures with the aim to use the less invasive approach according to the specific patient characteristics. The trans-subclavian approach should be the preferred option in patients with femoral arterial disease undergoing TAVI; however, self-expandable valves have potential limitations, as in case of ascending aorta dilation and high implantation.

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Drug-eluting stents (DES) have significantly improved the outcome of percutaneous coronary intervention (PCI); however, several concerns remain regarding late adverse events associated with the presence of a permanent rigid metallic cage that might impair the natural healing process of the coronary vessel wall. Recently, PCI with bioresorbable vascular scaffolds (BVS) has emerged as an interesting alternative with several potential advantages related to the complete resorption process that occurs within 3-5 years. As a consequence, it reduces the trigger for persistent inflammation, enables restoration of normal vessel reactivity and facilitates positive remodeling.

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Aims: Clinical trials have shown that transcatheter aortic valve implantation for aortic stenosis compares favorably to surgical replacement in high-risk patients and is superior to medical therapy in those at prohibitive risk. There is uncertainty however on patterns and trends in transcatheter aortic valve implantation, especially focusing on Italy.

Methods: The RISPEVA study is a prospective Italian registry including 21 institutions.

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