Role of endothelium in the mechanical response of the carotid arterial wall to calcium blockade in spontaneously hypertensive and Wistar-Kyoto rats.

Objectives: Calcium blockade has been reported to inhibit the contraction of the vascular smooth muscle and the liberation of vasoactive substances by endothelial cells. We tested the effects of calcium blockade on the mechanical properties of the carotid artery in normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) in the presence and in the absence of endothelium.

Methods: The pressure-volume relationships of isolated carotid arteries were recorded in situ in SHR (n = 20) and WKY rats (n = 20) before and after calcium blockade by local incubation with clentiazem.

Post marketing surveillance of zopiclone: interim analysis on the first 10,000 cases in a clinical study in general practice.

The tolerance of zopiclone, a hypnotic belonging to a new chemical group, the cyclopyrrolones, was studied in a follow-up trial in 23,000 insomniac outpatients treated for 3 weeks. The results from the interim analysis of the first 10,000 cases confirm the efficacy and safety of zopiclone under usual prescribing conditions. The average daily dose of zopiclone was 0.

Prognostic value of EBV markers in the clinical management of nasopharyngeal carcinoma (NPC): a multicenter follow-up study.

Between December 1979 and April 1982, 373 patients with untreated, undifferentiated carcinoma of the nasopharynx (NPC), 99 in Hong Kong, 120 in Tunis and 154 in Villejuif, entered a longitudinal study aimed at determining the clinical prognostic value of EBV serology after radiotherapy. A minimum of 3 years' follow-up was achieved for 319 patients (83 in Tunis, 95 in Hong Kong and 141 in Villejuif) who had regular clinical and serological testing at intervals of 6-8 months. No significant difference in initial serology (i.