Publications by authors named "C Pfannenberg"
Article Synopsis
- Immune checkpoint inhibitors (ICIs) have greatly improved survival rates for melanoma patients, but many suffer from serious side effects and there is a need for better early response indicators.
- A study involving 104 patients used circulating tumor DNA (ctDNA) as a biomarker to assess treatment response and recurrence, employing advanced sequencing techniques.
- Results showed that changes in ctDNA levels were linked to patient outcomes, indicating that tumor-informed liquid biopsies could effectively monitor treatment responses and detect early relapses in melanoma.
Preoperative Assessment of Medication-Related Osteonecrosis of the Jaw Using [18F]fluoride Positron Emission Tomography (PET)/CT and [18F]fluorodeoxyglucose PET/MRI in Correlation with Histomorphometry and Micro-CT-A Prospective Comparative Study.
Diagnostics (Basel)
February 2024
Objectives: The purpose of this study was to investigate the imaging characteristics of medication-related osteonecrosis of the jaw (MRONJ) using [18F]fluoride positron emission tomography/computed tomography (PET/CT) and [18F]fluorodeoxyglucose (FDG) PET/magnetic resonance imaging (MRI) for preoperative assessment and to correlate them with microarchitectural and histomorphometric data with respect to clinical findings.
Methods: Twelve patients (five female; mean age 75 ± 7.6 yr) with symptomatic MRONJ underwent both scans on the same day, and imaging findings were used to plan surgical interventions for seven patients.
Purpose: To investigate the impact of [F]FDG-PET/CT on the management of differentiated thyroid carcinoma (DTC) in routine clinical settings.
Material And Methods: In total, 98 patients (55 females, age 56 ± 18 years) with histologically confirmed thyroid cancer, including all types of DTC and poorly differentiated thyroid cancer (PDTC, n = 7), underwent [F]FDG-PET/CT for staging or recurrence diagnostics performed using a state-of-the art clinical scanner (Biograph mCT, Siemens Healthineers) with a standardized examination protocol. The impact of PET/CT on clinical decision making was prospectively evaluated using standardized questionnaires completed by the referring physicians before and after PET/CT.