Publications by authors named "C Perucca Orfei"
Article Synopsis
- - Muscle disorders caused by tendon issues lead to reduced muscle function and atrophy, and Pulsed Electromagnetic Fields (PEMFs) may help improve tendon structure and muscle recovery.
- - A study on rats with induced Achilles tendinopathy showed that PEMF therapy resulted in significant metabolic changes, improving NAD signaling, ATP production, and enhancing the function of proteins related to muscle recovery.
- - The research demonstrated that PEMF treatment not only increased antioxidant protein levels but also restored important signaling proteins like PGC1alpha and YAP, and upregulated slow myosin isoforms, facilitating faster physiological recovery of muscle tissue.
Aim Of The Study: Tendons are exposed to mechanical stress constantly during movements and thus they are frequently subjected to injuries. Rotator cuff tears are common musculoskeletal disorders, mainly involving the supraspinatus tendon. The characterization of the tenocytes derived from this tendon and the comparison to cells isolated from the long head of the biceps tendon obtained from donors affected by rotator cuff disease may improve the knowledge of the cellular mechanisms involved in the initiation and progression of the pathology.
View Article and Find Full Text PDFPurpose: this study was conducted to characterize tendon stem/progenitor cells (TSPCs) isolated from human semitendinosus and gracilis tendons in terms of stemness properties and multi-differentiation potential.
Methods: TSPCs were isolated from waste portions of semitendinosus and gracilis tendons from three donors who underwent anterior cruciate ligament reconstruction. TSPCs were plated in culture until passage 4, when experiments to assess cell proliferation, viability and clonogenic ability were performed.