Safety of ninety-minute daratumumab infusion.

Purpose: Daratumumab is the first anti-CD38 monoclonal antibody of the class approved for recurrent and refractory multiple myeloma. Grade 3 and 4 Infusion-Related Reactions (IRRs) are frequent during the first and second infusions. Due to the risks associated with severe IRRs, daratumumab is systematically administered over a period of 3.

Clinical and economic impact of pharmacist interventions in an ambulatory hematology-oncology department.

Objectives: To evaluate clinical and financial impact of pharmacist interventions in an ambulatory adult hematology-oncology department.

Methods: All cancer patients receiving a first injectable immuno- and/or chemotherapy regimen were included in this prospective study over a one-year period. The clinical impact of pharmacist interventions made by two clinical pharmacists was rated using the Clinical Economic and Organizational tool.

Influence of Root System Characteristics on Black Spruce Seedling Responses to Limiting Conditions.

Roots directly affect planted seedling adaptation to new growing conditions at reforestation sites. To test the influence of root characteristics on the short-term response of seedlings to limiting resources (water, nutrient, or oxygen), we conducted two experiments. We compared (1) the growth and physiology of three types of four-year-old black spruce ( (Mill.

The need for a timely diagnostic workup for patients with venous leg ulcers.

Objective: To explore the need for an extended diagnostic workup in patients with venous leg ulcers (VLUs) and to establish the prevalence of the underlying causes of VLU.

Method: This retrospective cohort study analysed data from patients with VLU. The visual analogue scale (VAS) was used for pain assessment.