Data-driven discovery of cell-type-directed network-correcting combination therapy for Alzheimer's disease.

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by heterogeneous molecular changes across diverse cell types, posing significant challenges for treatment development. To address this, we introduced a cell-type-specific, multi-target drug discovery strategy grounded in human data and real-world evidence. This approach integrates single-cell transcriptomics, drug perturbation databases, and clinical records.

The disease-causing tau V337M mutation induces tau hypophosphorylation and perturbs axon morphology pathways.

Tau aggregation is a hallmark of several neurodegenerative diseases, including Alzheimer's disease and frontotemporal dementia. There are disease-causing variants of the tau-encoding gene, , and the presence of tau aggregates is highly correlated with disease progression. However, the molecular mechanisms linking pathological tau to neuronal dysfunction are not well understood due to our incomplete understanding of the normal functions of tau in development and aging and how these processes change in the context of causal disease variants of tau.

Validation of Cameriere's medical-legal age estimation method using seconds premolars in a Portuguese population.

The goal of this project is to validate the Cameriere's method applied to the upper and lower second premolars in a Portuguese population, regarding the forensic estimate of age. The applied sample consisted in 100 panoramic radiographs, of 60 males and 40 females, patients of the Faculty of Dental Medicine of the University of Lisbon, whose ages vary between 15 and 35 years old. Thus, a total of 400 teeth were investigated (200 upper second premolars and 200 lower second premolars).

[Hyperplastic polyp of the colon].

On re-examining 477 polyps of the colon obtained by endoscopic polypectomy, the authors describe a type of polyp with they have called hyperplasiogenous. This polyp is characterised by a proliferation of rectilinear glands, divided at their base, forming a connecting spur; this spur may form a more complex alveolar or tubulo-alveolar structure. The glands have cells with a tall, clear cytoplasm and a small, homogeneous nucleus with no irregularities or metaplasia.