Publications by authors named "C Penfold"
Article Synopsis
- - The study investigates early human trophoblast development using marmoset embryos, bridging gaps in understanding due to the inaccessibility of human early conceptus.
- - Researchers successfully created trophoblast stem cells (TSCs) from marmoset pluripotent stem cells, demonstrating unique characteristics and differentiation potential compared to human TSCs.
- - The findings suggest that specific culture conditions for marmosets can maintain a trophoblast-like identity, revealing insights into evolutionary differences in implantation and enhancing knowledge of human development.
Objectives: Our aim was to identify which patients are likely to stay in hospital longer following total hip replacement surgery.
Design: Longitudinal, observational study used routinely collected data.
Setting: Data were collected from an NHS Trust in South-West England between 2016 and 2019.
Background: OX40 has been widely studied as a target for immunotherapy with agonist antibodies taken forward into clinical trials for cancer where they are yet to show substantial efficacy. Here, we investigated potential mechanisms of action of anti-mouse (m) OX40 and anti-human (h) OX40 antibodies, including a clinically relevant monoclonal antibody (mAb) (GSK3174998) and evaluated how isotype can alter those mechanisms with the aim to develop improved antibodies for use in rational combination treatments for cancer.
Methods: Anti-mOX40 and anti-hOX40 mAbs were evaluated in a number of in vivo models, including an OT-I adoptive transfer immunization model in hOX40 knock-in (KI) mice and syngeneic tumor models.
Background: The Additional Roles Reimbursement Scheme (ARRS) was introduced by NHS England in 2019 alongside primary care networks (PCNs), with the aims of increasing the workforce and improving patient outcomes.
Aim: To describe the uptake of direct patient care (DPC)-ARRS roles and its impact on patients' experiences.
Design And Setting: An ecological study using 2020-2023 PCN and practice workforce data, registered patient characteristics, the General Practice Patient Survey, and the Quality and Outcomes Framework (QOF).
The sperm epigenome is thought to affect the developmental programming of the resulting embryo, influencing health and disease in later life. Age-related methylation changes in the sperm of old fathers may mediate the increased risks for reproductive and offspring medical problems. The impact of paternal age on sperm methylation has been extensively studied in humans and, to a lesser extent, in rodents and cattle.
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