Publications by authors named "C Peach"
G protein-coupled receptor (GPCR) endocytosis is canonically associated with β-arrestins. Here, we delineate a β-arrestin-independent endocytic pathway driven by the cytoskeletal motor, myosin VI. Myosin VI engages GIPC, an adaptor protein that binds a PDZ sequence motif present at the C-terminus of several GPCRs.
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- The audit aimed to assess and improve the completeness and accuracy of the National Joint Registry (NJR) dataset specifically for elbow arthroplasty surgeries.
- In a two-phase approach, Phase 1 compared NJR data with NHS England Hospital Episode Statistics (HES), identifying thousands of unmatched and inaccurate records, particularly for radial head arthroplasties (RHAs).
- Phase 2 involved collaboration among 142 NHS hospitals to correct and update records, resulting in an improved completeness of the NJR dataset from 63% to 93% and accuracy from 94% to 98%.
Nerve growth factor (NGF) monoclonal antibodies inhibit chronic pain yet failed to gain approval due to worsened joint damage in osteoarthritis patients. We report that neuropilin-1 (NRP1) is a co-receptor for NGF and tropomyosin-related kinase A (TrkA) pain signaling. NRP1 was coexpressed with TrkA in human and mouse nociceptors.
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- Oral cancer causes significant pain linked to the activation of protease-activated receptor 2 (PAR) in cancer cells and neurons, contributing to nociception (pain sensation).
- Researchers found that inhibiting PAR using nanoparticles to deliver the drug AZ3451 is more effective in reversing pain compared to the drug alone, especially in mouse models of oral cancer pain.
- The study also shows that both the overexpression of the F2RL1 gene in cancer cells and neurons plays a role in pain, and targeting PAR could improve pain management and oral function for patients.