Publications by authors named "C Patrat"
About one in six couples experience fertility problems, and male infertility accounts for about half of these cases. Spermatogenesis originates from a small pool of spermatogonial stem cells (SSCs), which are of interest for the treatment of infertility but remain poorly characterised in humans. Using multiparametric spectral flow cytometric analysis with a 16-colours (16-C) panel of cell markers, we identify novel markers of SSCs and provide insights into unravelling and resolving the heterogeneity of the human spermatogonial cells.
View Article and Find Full Text PDFAssisted reproductive technologies have offered new ways and pathways to conceive a child. However, very few is known about insights into the complexities and challenges faced by trans fathers in contemporary parenthood journeys. This qualitative study explores the experiences of transgender and cisgender fathers who conceived children through donor sperm insemination (DSI) and natural conception (NC).
View Article and Find Full Text PDFObjective: To provide evidence regarding the significance of painful symptoms among women suffering from infertility.
Design: An observational retrospective cross-sectional study.
Settings: University hospital-based research center.
Study Question: Do women with endometriosis who achieve a live birth (LB) after HRT-frozen embryo transfer (HRT-FET) have different progesterone levels on the day of transfer compared to unaffected women?
Summary Answer: In women achieving a LB after HRT-FET, serum progesterone levels on the day of the transfer did not differ between patients with endometriosis and unaffected patients.
What Is Known Already: In HRT-FET, several studies have highlighted the correlation between serum progesterone levels at the time of FET and LB rates. In the pathophysiology of endometriosis, progesterone resistance is typically described in the eutopic endometrium.
Article Synopsis
- The study explores how human embryos undergo compaction, which is crucial for their development, revealing that defects in adhesion lead to compaction failure.
- Researchers used micropipette aspiration to investigate cell surface tensions during compaction, finding that increased tension at the cell-medium interface is critical for this process, mirroring findings in mouse embryos but showing less efficiency in humans.
- The research highlights the distinct roles of cell contractility and cell-cell adhesion in embryo compaction, showing that contractility is essential for generating the forces required for the initial morphogenetic movements in human development.