Publications by authors named "C Pasquale"
Purpose: Uniparental disomy (UPD) is a genetic condition which both copies of a chromosome are inherited from a single parent, potentially leading to imprinting disorders. This study aimed to assess the integration of Short Tandem Repeat (STR) analysis into Preimplantation Genetic Testing for Structural Rearrangements (PGT-SR) to assess UPD risk and its impact on selecting euploid embryos for embryo transfer in couples with chromosomal translocations involving imprinted chromosomes.
Methods: This study evaluated three couples carrying balanced chromosomal translocations: 45,XX,der(13;14)(q10;q10), 46,XX,t(10;11)(q22;q13), and 45,XY,der(14;15)(q10;q10).
Aims: The relationship between body mass index (BMI) and clinical outcomes in patients with cardiovascular disease, including acute heart failure (AHF) and acute myocardial infarction (AMI), remains debated. This study investigates the association between BMI and clinical outcomes within the PARADISE-MI cohort, while also evaluating the impact of angiotensin receptor-neprilysin inhibitor (ARNI) versus angiotensin-converting enzyme inhibitor (ACE-I) treatment on this relationship.
Methods And Results: The analysis included 5589 patients from the PARADISE-MI study with available baseline BMI data.
: Uterus transplantation (UTx) is currently the only available treatment for absolute uterine factor infertility. Deceased donors have recently emerged as a valid alternative to living donors for uterus transplantation, with similar results. : We report the first experience in Italy of uterus transplantation from deceased donors.
View Article and Find Full Text PDFA Cross-Sectional Study of Capillary Blood Ketone Concentrations in Heart Failure Based on Sodium-Glucose Co-Transporter-2 Inhibitor Use and Heart Failure Type.
Heart Lung Circ
November 2024
Article Synopsis
- Sodium-glucose co-transporter 2 inhibitors (SGLT2i) are commonly used in treating heart failure (HF), but their association with ketosis risk during hospitalization is uncertain.
- A study measured ketone levels in hospitalized patients with worsening HF and stable HF to determine if SGLT2i use influenced ketone concentrations.
- Results showed that ketone levels were low across all patients, regardless of SGLT2i use or the severity of heart failure, indicating minimal risk of ketosis in these individuals.
Article Synopsis
- * It used the Delphi method to gather expert opinions, leading to consensus on key aspects such as when to prescribe TAI and the techniques to use, ultimately establishing guidelines that clinicians and nurses can follow.
- * The resulting protocol aims to improve patient care and outcomes by addressing technical challenges and providing clear recommendations for the use of TAI in these patients.