Publications by authors named "C Parra-Farinas"

Image guidance is becoming standard of practice for cerebrospinal fluid sampling in children to improve success rates and avoid complications. This article discusses various imaging guidance techniques available in the pediatric age group. For neonates and infants, imaging guidance using ultrasound is the technique of choice, and for older children, fluoroscopy or even cone beam computed tomography can be used when anatomy is complex.

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Intracranial arterial aneurysms in children are rare. They differ from adult aneurysms in their etiology, natural history, and management approach. Unruptured asymptomatic aneurysms in children can often be observed for growth over time.

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Background: Emerging evidence suggests that endovascular thrombectomy is beneficial for treatment of childhood stroke, but the safety and effectiveness of endovascular thrombectomy has not been compared with best medical treatment. We aimed to prospectively analyse functional outcomes of endovascular thrombectomy versus best medical treatment in children with intracranial arterial occlusion stroke.

Methods: In this prospective registry study, 45 centres in 12 countries across Asia and Australia, Europe, North America, and South America reported functional outcomes for children aged between 28 days and 18 years presenting with arterial ischaemic stroke caused by a large-vessel or medium-vessel occlusion who received either endovascular thrombectomy plus best medical practice or best medical treatment alone.

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Article Synopsis
  • The study aimed to compare outcomes of single-agent (melphalan) versus triple-agent (melphalan, topotecan, carboplatin) intra-arterial chemotherapy for retinoblastoma (RB) in children, focusing on eye salvage.
  • Researchers reviewed cases of 37 children under 18 who underwent intra-arterial chemotherapy from 2016 to 2024, analyzing complications, tumor responses, and survival rates.
  • Results showed that the triple-agent therapy had a higher rate of partial or complete tumor response (91% vs. 62%), but ocular complications were similar between both groups (31% single-agent vs. 52% triple-agent).
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Pediatric interventional radiology is a dynamic and growing subspecialty. The new training pathways in interventional radiology, the maintenance of skills with a small volume of cases or complex procedures, the limited availability of specific pediatric equipment and materials pose significant challenges and opportunities.

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