Orange Peel : Development of A Mucoadhesive Nasal Spray with Antimicrobial and Anti-inflammatory Activity.

Due to the high frequency and severity of upper respiratory bacterial infections, probiotics could offer a new medical approach. We explored the antibacterial and anti-inflammatory properties of the new strain BIA and formulated a nasal spray. BIA was isolated from orange peel and taxonomically identified through 16S rRNA gene sequencing.

Protective Mechanisms of Vaginal Lactobacilli against Sexually Transmitted Viral Infections.

The healthy cervicovaginal microbiota is dominated by various species, which support a condition of eubiosis. Among their many functions, vaginal lactobacilli contribute to the maintenance of an acidic pH, produce antimicrobial compounds, and modulate the host immune response to protect against vaginal bacterial and fungal infections. Increasing evidence suggests that these beneficial bacteria may also confer protection against sexually transmitted infections (STIs) caused by viruses such as human papillomavirus (HPV), human immunodeficiency virus (HIV) and herpes simplex virus (HSV).

Simultaneous Expression of Different Therapeutic Genes by Infection with Multiple Oncolytic HSV-1 Vectors.

Oncolytic viruses (OVs) are anti-cancer therapeutics combining the selective killing of cancer cells with the triggering of an anti-tumoral immune response. The latter effect can be improved by arming OVs with immunomodulatory factors. Due to the heterogeneity of cancer and the tumor microenvironment, it is anticipated that strategies based on the co-expression of multiple therapeutic molecules that interfere with different features of the target malignancy will be more effective than mono-therapies.

Unpredictable Dynamic Behaviour of Ruthenium Chelate Pyrrole Derivatives.

Reaction of [Ru(H)(CO)(PPh)] with an equimolar amount of pyrrole-2-carboxylic acid () leads to the homoleptic chelate derivative k(O,O)-[RuH(CO)(HL)(PPh)] . Prolonged acetonitrile refluxing promotes an unusual k(O,O)- → k(N,O)- dynamic chelate conversion, forming a neutral, stable, air- and moisture- insensitive, solvento-species k(N,O)-[Ru(MeCN)(CO)(L)(PPh)] . Analogously, reaction of with the pyrrole-2-carboxyaldehyde () affords k(N,O)-[RuH(CO)(HL)(PPh)] , , as a couple of functional isomers.