Publications by authors named "C Papanikolaou"
: DNA damage response (DDR) is a network of molecular pathways associated with the pathogenesis and progression of several diseases, as well as the outcome of chemotherapy. Moreover, the intracellular redox status is essential for maintaining cell viability and controlling cellular signaling. Herein, we analyzed DDR signals and redox status in peripheral blood mononuclear cells (PBMCs) from patients with lung cancer with different response rates to platinum-based chemotherapy.
View Article and Find Full Text PDFRemission of asthma can occur as part of the natural history of the disease; however, the use of biologics can result in disease remission in some patients. In this post hoc analysis of the RELIght study, we aimed to evaluate clinical remission in real life among patients treated with mepolizumab, to detect possible differences between "remitters" and "nonremitters," and to evaluate possible predictors of remission. Clinical remission was defined as the absence of asthma exacerbations, discontinuation of oral corticosteroids (OCS), achievement of asthma control (Asthma Control Test [ACT] ≥ 20), and stable or improved lung function.
View Article and Find Full Text PDFArticle Synopsis
- The DNA damage response (DDR) and mitogen-activated protein kinase (MAPK) signaling pathways are essential for the survival of living organisms, and their interactions are important for proper cellular function.
- Abnormalities in these pathways are linked to various diseases, particularly cancer and drug resistance, highlighting the need for further research.
- The latest findings in treating multiple myeloma focus on targeting components of the DDR and MAPK pathways, opening up opportunities for new therapeutic strategies and clinical trials.
Article Synopsis
- The ongoing debate around accurately modeling gaze patterns poses challenges for analyzing eye-tracking data, but a Lévy flight model may offer a solution due to its scale-invariant characteristics.
- Our research indicates that children with ADHD show distinct differences in the characteristics of their eye-gaze patterns compared to non-ADHD children, reflecting a less optimal search strategy.
- Combining eye-tracking data with traditional cognitive tests could enhance ADHD diagnosis, as it allows for seamless data collection without additional time commitments.
Article Synopsis
- This text discusses a unique type of yeast capable of storing over 70% lipids by weight when grown in nitrogen-limited environments with sufficient carbon.
- It highlights the need to better understand how different levels of glucose and ammonium sulfate affect yeast growth and lipid creation, beyond the initial focus on carbon-to-nitrogen ratios.
- The study aims to create improved cultivation methods by balancing carbon and nitrogen inputs, which could lead to more efficient microbial oil production and advance its commercial viability.