Publications by authors named "C Pamela Graves"
A Cetylpyridinium Chloride Oral Rinse Reduces Salivary Viral Load in Randomized Controlled Trials.
JDR Clin Trans Res
December 2024
Introduction: Evaluating the antiviral potential of commercially available mouthrinses on SARS-CoV-2 holds potential for reducing transmission, particularly as novel variants emerge. Because SARS-CoV-2 is transmitted primarily through salivary and respiratory secretions and aerosols, strategies to reduce salivary viral burden in an antigen-agnostic manner are attractive for mitigating spread in dental, otolaryngology, and orofacial surgery clinics where patients may need to unmask.
Methods: Patients ( = 128) with confirmed COVID-19-positive status within 10 days of symptom onset or positive test result were enrolled in a double-blind randomized controlled trial of Food and Drug Administration-approved mouthrinses containing active ingredients ethanol, hydrogen peroxide, povidone iodine, chlorhexidine gluconate, cetylpyridinium chloride (CPC), or saline.
Article Synopsis
- Tissue-specific immune responses play a crucial role in maintaining health and regulating diseases, particularly in the context of COVID-19, where oral immune responses can reveal insights about the body's overall reaction to the virus.
- A study analyzed saliva from 227 COVID-19 positive participants and 37 controls, identifying significant changes in 25 cytokines related to the immune response during early infection, including downregulation of type I/III interferons and altered natural killer/T-cell activity.
- The findings underscore the importance of saliva as a biomarker for monitoring immune responses to SARS-CoV-2 and highlight how vaccination can enhance salivary antibody levels, suggesting oral immune dysregulation during early infection may aid viral evasion.
Article Synopsis
- * Delays in diagnosing CVD represent a significant missed opportunity for timely interventions that could improve maternal health outcomes.
- * Implementing universal CVD risk assessments for all pregnant and postpartum patients and integrating validated tools into routine care can enhance awareness, promote early diagnosis, and ultimately reduce maternal deaths related to CVD.