Hepatobiliary scintigraphy and gamma-GT levels in the differential diagnosis of extrahepatic biliary atresia.

Aim: The aim of this paper is to identify extrahepatic biliary atresia (EHBA) as the cause of cholestasis in neonates with prolonged jaundice and thus accelerate the decision for surgical intervention, which is critical for prognosis.

Methods: We retrospectively studied 21 infants (13 girls, 8 boys) aged 2-16 weeks who have undergone( 99m)Tc-mebrofenin iminodiacetate ((99m)Tc-BrIDA) scintigraphy. They were referred because of direct hyperbilirubinemia and jaundice persisting beyond the 2nd postnatal week.

Value of thyroglobulin to 131I uptake ratio in selection of initial therapy dose of 131I in patients with differentiated thyroid carcinoma.

Aim: To test the hypothesis that the ratio of thyroglobulin (Tg) to 131I uptake in the thyroid bed during the immediate post-thyroidectomy work-up could be used before first 131I treatment to detect patients with residual or metastatic thyroid cancer and justify the administration of a higher ablation dose in selected cases and a possibly better therapeutic effect.

Methods: We retrospectively studied 293 patients with differentiated thyroid carcinoma that received their first 131I treatment in our department. Patients with Tg >100 ng/mL, 131I uptake >10% and measurable Tg-specific autoantibodies, were excluded.